Synaptotagmins: That’s why so many Journal Article


Author(s): Chen, Chong; Jonas, Peter
Article Title: Synaptotagmins: That’s why so many
Affiliation IST Austria
Abstract: Synaptotagmin 7 (Syt7) was originally identified as a slow Ca2+ sensor for lysosome fusion, but its function at fast synapses is controversial. The paper by Luo and Südhof (2017) in this issue of Neuron shows that at the calyx of Held in the auditory brainstem Syt7 triggers asynchronous release during stimulus trains, resulting in reliable and temporally precise high-frequency transmission. Thus, a slow Ca2+ sensor contributes to the fast signaling properties of the calyx synapse.
Journal Title: Neuron
Volume: 94
Issue 4
ISSN: 0896-6273
Publisher: Elsevier  
Date Published: 2017-05-17
Start Page: 694
End Page: 696
DOI: 10.1016/j.neuron.2017.05.011
Open access: no