Evolution of new regulatory functions on biophysically realistic fitness landscapes Journal Article


Author(s): Friedlander, Tamar; Prizak, Roshan; Barton, Nicholas H; Tkačik, Gašper
Article Title: Evolution of new regulatory functions on biophysically realistic fitness landscapes
Affiliation IST Austria
Abstract: Gene expression is controlled by networks of regulatory proteins that interact specifically with external signals and DNA regulatory sequences. These interactions force the network components to co-evolve so as to continually maintain function. Yet, existing models of evolution mostly focus on isolated genetic elements. In contrast, we study the essential process by which regulatory networks grow: the duplication and subsequent specialization of network components. We synthesize a biophysical model of molecular interactions with the evolutionary framework to find the conditions and pathways by which new regulatory functions emerge. We show that specialization of new network components is usually slow, but can be drastically accelerated in the presence of regulatory crosstalk and mutations that promote promiscuous interactions between network components.
Journal Title: Nature Communications
Volume: 8
ISSN: 2041-1723
Publisher: Nature Publishing Group  
Date Published: 2017-08-09
Start Page: Article number: 216
Sponsor: Marie Curie Actions of the European Union’s Seventh Framework Programme (FP7/2007–2013) grant agreement Nr. 291734 (T.F.), ERC grant Nr. 250152 (N.B.), FWF P28844 (G.T.)
URL:
DOI: 10.1038/s41467-017-00238-8
Open access: yes (OA journal)