Different patterns of neuronal activity trigger distinct responses of oligodendrocyte precursor cells in the corpus callosum Journal Article


Author(s): Nagy, Balint; Hovhannisyan, Anahit; Barzan, Ruxandra; Chen, Ting-Jiun; Kukley, Maria
Article Title: Different patterns of neuronal activity trigger distinct responses of oligodendrocyte precursor cells in the corpus callosum
Affiliation IST Austria
Abstract: In the developing and adult brain, oligodendrocyte precursor cells (OPCs) are influenced by neuronal activity: they are involved in synaptic signaling with neurons, and their proliferation and differentiation into myelinating glia can be altered by transient changes in neuronal firing. An important question that has been unanswered is whether OPCs can discriminate different patterns of neuronal activity and respond to them in a distinct way. Here, we demonstrate in brain slices that the pattern of neuronal activity determines the functional changes triggered at synapses between axons and OPCs. Furthermore, we show that stimulation of the corpus callosum at different frequencies in vivo affects proliferation and differentiation of OPCs in a dissimilar way. Our findings suggest that neurons do not influence OPCs in “all-or-none” fashion but use their firing pattern to tune the response and behavior of these nonneuronal cells.
Journal Title: PLoS Biology
Volume: 15
Issue 8
ISSN: 1545-7885
Publisher: Public Library of Science  
Date Published: 2017-08-22
Start Page: Article nzmber: e2001993
Copyright Statement: CC BY
URL:
DOI: 10.1371/journal.pbio.2001993
Notes: Funding: Deutsche Forschungsgemeinschaft http://www.dfg.de (grant number EXC307). MK received funding for her research group and for this work from the Werner Reichardt Centre for Integrative Neuroscience (CIN) at the Eberhard Karls University of Tübingen. The CIN is an Excellence Cluster funded by the Deutsche Forschungsgemeinschaft (DFG) within the framework of the Excellence Initiative (EXC 307). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Deutsche Forschungsgemeinschaft http://www.dfg.de (grant number KU2569/1-1). Received by MK. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments:We thank Bill Stallcup (Burnham Institute, USA) for the gift of NG2 antibodies, Rick Gerkin (Arizona State University, USA) for help with setting up the acquisition software, and Alejandro Pernía-Andrade (IST, Klosterneuburg, Austria) for help with setting up FBrain. We thank Jeffrey Diamond (Bethesda, Maryland, USA) and the members of Kukley’s laboratory Bartosz Kula and Friederike Pfeiffer for comments on the earlier version of the manuscript.
Open access: yes (OA journal)