Optomechanical proposal for monitoring microtubule mechanical vibrations Journal Article


Author(s): Barzanjeh, Shabir; Salari, Vahid; Tuszynski, Jack A; Cifra, Michal; Simon, Christoph
Article Title: Optomechanical proposal for monitoring microtubule mechanical vibrations
Affiliation IST Austria
Abstract: Microtubules provide the mechanical force required for chromosome separation during mitosis. However, little is known about the dynamic (high-frequency) mechanical properties of microtubules. Here, we theoretically propose to control the vibrations of a doubly clamped microtubule by tip electrodes and to detect its motion via the optomechanical coupling between the vibrational modes of the microtubule and an optical cavity. In the presence of a red-detuned strong pump laser, this coupling leads to optomechanical-induced transparency of an optical probe field, which can be detected with state-of-the art technology. The center frequency and line width of the transparency peak give the resonance frequency and damping rate of the microtubule, respectively, while the height of the peak reveals information about the microtubule-cavity field coupling. Our method opens the new possibilities to gain information about the physical properties of microtubules, which will enhance our capability to design physical cancer treatment protocols as alternatives to chemotherapeutic drugs.
Keywords: Brain; in vitro study; theoretical model; neuroscience; Axon; myelin sheath; photon; travel
Journal Title: Physical Review E Statistical Nonlinear and Soft Matter Physics
Volume: 96
Issue 1
ISSN: 1539-3755
Publisher: American Institute of Physics  
Date Published: 2017-07-12
Start Page: Article number: ea012404
URL:
DOI: 10.1103/PhysRevE.96.012404
Notes: S.B. acknowledges support from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska Curie Grant No. 707438 (MSC-IF SU- PEREOM). M.C. acknowledges funding from Czech Science Foundation, Project No. P102/15-17102S, and participates in COST Actions No. BM1309 and No. CA15211, and Project No. SAV-15-22 between Czech and Czech Academies of Sciences. J.A.T. and C.S. acknowledge research funding from NSERC (Canada).
Open access: yes (repository)