Effects of B vitamins overload on plasma insulin level and hydrogen peroxide generation in rats Journal Article


Author(s): Sun, Wuping; Zhai, Mingzhu; Zhou, Qian; Qian, Chengrui; Jiang, Changyu
Article Title: Effects of B vitamins overload on plasma insulin level and hydrogen peroxide generation in rats
Affiliation IST Austria
Abstract: It has been reported that nicotinamide-overload induces oxidative stress associated with insulin resistance, the key feature of type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of B vitamins in T2DM. Glucose tolerance tests (GTT) were carried out in adult Sprague-Dawley rats treated with or without cumulative doses of B vitamins. More specifically, insulin tolerance tests (ITT) were also carried out in adult Sprague-Dawley rats treated with or without cumulative doses of Vitamin B3. We found that cumulative Vitamin B1 and Vitamin B3 administration significantly increased the plasma H2O2 levels associated with high insulin levels. Only Vitamin B3 reduced muscular and hepatic glycogen contents. Cumulative administration of nicotinic acid, another form of Vitamin B3, also significantly increased plasma insulin level and H2O2 generation. Moreover, cumulative administration of nicotinic acid or nicotinamide impaired glucose metabolism. This study suggested that excess Vitamin B1 and Vitamin B3 caused oxidative stress and insulin resistance.
Keywords: Oxidative Stress; B vitamins; insulin resistance; nicotinamide nicotinic acid
Journal Title: Chinese Journal of Physiology
Volume: 60
Issue 4
ISSN: 03044920
Publisher: Chinese Physiological Society  
Date Published: 2017-08-31
Start Page: 207
End Page: 214
Sponsor: This work was supported by grants from Shenzhen Municipal Science, Technology and Innovation Commission (No. JCYJ20160429182122843, No. JCYJ20160429181451546), Municipal Key Laboratory Program of Shenzhen (No. ZD-SYS20140509150415945).
DOI: 10.4077/CJP.2017.BAF469
Open access: no