Genetic and pharmacological reversibility of phenotypes in mouse models of autism spectrum disorder Book Section


Author(s): Schroeder, Jan C; Deliu, Elena; Novarino, Gaia; Schmeisser, Michael J
Article/Chapter Title: Genetic and pharmacological reversibility of phenotypes in mouse models of autism spectrum disorder
Title Series: ADVSANAT
Affiliation IST Austria
Abstract: As autism spectrum disorder (ASD) is largely regarded as a neurodevelopmental condition, long-time consensus was that its hallmark features are irreversible. However, several studies from recent years using defined mouse models of ASD have provided clear evidence that in mice neurobiological and behavioural alterations can be ameliorated or even reversed by genetic restoration or pharmacological treatment either before or after symptom onset. Here, we review findings on genetic and pharmacological reversibility of phenotypes in mouse models of ASD. Our review should give a comprehensive overview on both aspects and encourage future studies to better understand the underlying molecular mechanisms that might be translatable from animals to humans.
Book Title: Translational Anatomy and Cell Biology of Autism Spectrum Disorder
Volume: 224
ISBN: 03015556
Publisher: Springer  
Date Published: 2017-05-28
Start Page: 189
End Page: 211
DOI: 10.1007/978-3-319-52498-6_10
Open access: no
IST Austria Authors
  1. Elena Deliu
    5 Deliu