Mechanisms of radial glia progenitor cell lineage progression Journal Article


Author(s): Beattie, Robert; Hippenmeyer, Simon
Article Title: Mechanisms of radial glia progenitor cell lineage progression
Affiliation IST Austria
Abstract: The mammalian cerebral cortex is responsible for higher cognitive functions such as perception, consciousness, and acquiring and processing information. The neocortex is organized into six distinct laminae, each composed of a rich diversity of cell types which assemble into highly complex cortical circuits. Radial glia progenitors (RGPs) are responsible for producing all neocortical neurons and certain glia lineages. Here, we discuss recent discoveries emerging from clonal lineage analysis at the single RGP cell level that provide us with an inaugural quantitative framework of RGP lineage progression. We further discuss the importance of the relative contribution of intrinsic gene functions and non-cell-autonomous or community effects in regulating RGP proliferation behavior and lineage progression.
Keywords: Neurogenesis; Cerebral Cortex; clonal analysis; mosaic analysis with double markers; neuroscience; gliogenesis; neurodevelopment; radialglia progenitor; single-cell labeling
Journal Title: FEBS letters
Volume: 591
ISSN: 1873-3468
Publisher: Wiley-Blackwell  
Date Published: 2017-12-01
Start Page: 3993
End Page: 4008
Copyright Statement: CC BY-NC
Sponsor: IST Austria Institutional Funds; program grant from the Human Frontiers Science Program (RGP0053/2014); People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/ 2007 – 2013) under REA grant agreement no 618444
URL:
DOI: 10.1002/1873-3468.12906
Notes: We thank all members of the Hippenmeyer laboratory for discussion and comments on the manuscript.
Open access: yes (OA journal)