Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain Journal Article


Author(s): Letts, James A; Sazanov, Lenoid
Article Title: Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain
Affiliation IST Austria
Abstract: The oxidative phosphorylation electron transport chain (OXPHOS-ETC) of the inner mitochondrial membrane is composed of five large protein complexes, named CI-CV. These complexes convert energy from the food we eat into ATP, a small molecule used to power a multitude of essential reactions throughout the cell. OXPHOS-ETC complexes are organized into supercomplexes (SCs) of defined stoichiometry: CI forms a supercomplex with CIII2 and CIV (SC I+III2+IV, known as the respirasome), as well as with CIII2 alone (SC I+III2). CIII2 forms a supercomplex with CIV (SC III2+IV) and CV forms dimers (CV2). Recent cryo-EM studies have revealed the structures of SC I+III2+IV and SC I+III2. Furthermore, recent work has shed light on the assembly and function of the SCs. Here we review and compare these recent studies and discuss how they have advanced our understanding of mitochondrial electron transport.
Journal Title: Nature Structural and Molecular Biology
Volume: 24
Issue 10
ISSN: 1545-9993
Publisher: Nature Publishing Group  
Date Published: 2017-10-05
Start Page: 800
End Page: 808
Sponsor: This work was supported in part by European Union’s 2020 Research and Innovation Program under grant 701309.
DOI: 10.1038/nsmb.3460
Open access: no