Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum Journal Article


Author(s): Simonnet, Jean; Nassar, Mérie; Stella, Federico; Cohen, Ivan; Mathon, Bertrand; Boccara, Charlotte N; Miles, Richard; Fricker, Desdemona
Article Title: Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum
Affiliation IST Austria
Abstract: Orientation in space is represented in specialized brain circuits. Persistent head direction signals are transmitted from anterior thalamus to the presubiculum, but the identity of the presubicular target neurons, their connectivity and function in local microcircuits are unknown. Here, we examine how thalamic afferents recruit presubicular principal neurons and Martinotti interneurons, and the ensuing synaptic interactions between these cells. Pyramidal neuron activation of Martinotti cells in superficial layers is strongly facilitating such that high-frequency head directional stimulation efficiently unmutes synaptic excitation. Martinotti-cell feedback plays a dual role: precisely timed spikes may not inhibit the firing of in-tune head direction cells, while exerting lateral inhibition. Autonomous attractor dynamics emerge from a modelled network implementing wiring motifs and timing sensitive synaptic interactions in the pyramidal - Martinotti-cell feedback loop. This inhibitory microcircuit is therefore tuned to refine and maintain head direction information in the presubiculum.
Journal Title: Nature Communications
Volume: 8
ISSN: 2041-1723
Publisher: Nature Publishing Group  
Date Published: 2017-07-01
Start Page: Article number: 16032
Copyright Statement: CC BY
URL:
DOI: 10.1038/ncomms16032
Notes: This work was supported by the Region Ile-de-France and Fondation pour la recherch? Medicale (J.S.) and by ANR Grant JCJC R10206DD (D.F.). The research leading to these results also benefitted from the programme 'Investissements d'avenir' ANR-10-IAIHU-06, and we gratefully acknowledge financial support from the ERC (322721, R.M.). We thank Dominique Debanne for discussions, and Matthew Nolan and Bruno Delord for comments on the manuscript. In vivo spike-train data were collected in the lab of Edvard and May-Britt Moser (Trondheim, Norway).
Open access: yes (OA journal)