Theory of eppithelial cell shape transitions induced by mechanoactive chemical gradients Journal Article


Author(s): Dasbiswas, Kinjal; Hannezo, Edouard; Gov, Nir S
Article Title: Theory of eppithelial cell shape transitions induced by mechanoactive chemical gradients
Affiliation IST Austria
Abstract: Cell shape is determined by a balance of intrinsic properties of the cell as well as its mechanochemical environment. Inhomogeneous shape changes underlie many morphogenetic events and involve spatial gradients in active cellular forces induced by complex chemical signaling. Here, we introduce a mechanochemical model based on the notion that cell shape changes may be induced by external diffusible biomolecules that influence cellular contractility (or equivalently, adhesions) in a concentration-dependent manner—and whose spatial profile in turn is affected by cell shape. We map out theoretically the possible interplay between chemical concentration and cellular structure. Besides providing a direct route to spatial gradients in cell shape profiles in tissues, we show that the dependence on cell shape helps create robust mechanochemical gradients.
Journal Title: Biophysical Journal
Volume: 114
Issue 4
ISSN: 1542-0086
Publisher: Biophysical Society  
Date Published: 2018-02-27
Start Page: 968
End Page: 977
URL:
DOI: 10.1016/j.bpj.2017.12.022
Open access: yes (repository)