Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage Journal Article


Author(s): Kaucka Marketa; Petersen Julian; Tesarova Marketa; Szarowska Bara; Kastriti, Maria E; Xie Meng; Kicheva, Anna; Annusver Karl; Kasper Maria; Symmons Orsolya; Pan Leslie; Spitz Francois; Kaiser Jozef; Hovorakova Maria; Zikmund Tomas; Sunadome Kazunori; Matise Michael P; Wang Hui; Marklund Ulrika; Abdo Hind; Ernfors Patrik; Maire Pascal; Wurmser Maud; Chagin Andrei S; Fried Kaj; Adameyko Igor
Article Title: Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage
Affiliation IST Austria
Abstract: Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here, we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signals generated by neural structures: brain and olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal capsule, whereas the formation of a capsule roof is controlled by signals from the olfactory epithelium. Unexpectedly, the cartilage of the nasal capsule turned out to be important for shaping membranous facial bones during development. This suggests that conserved neurosensory structures could benefit from protection and have evolved signals inducing cranial cartilages encasing them. Experiments with mutant mice revealed that the genomic regulatory regions controlling production of SHH in the nervous system contribute to facial cartilage morphogenesis, which might be a mechanism responsible for the adaptive evolution of animal faces and snouts.
Journal Title: eLife
Volume: 7
ISSN: 2050-084X
Publisher: eLife Sciences Publications  
Publication Place: England
Date Published: 2018-06-13
Start Page: epub ahead of print
URL:
DOI: 10.7554/eLife.34465
Notes: Anna Kicheva lab is supported by the European Research Council under European Union Horizon 2020 research and innovation program grant 680037
Open access: yes (OA journal)
IST Austria Authors
  1. Anna Kicheva
    24 Kicheva
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