Autoregulation of bacterial gene expression: lessons from the MazEF toxin–antitoxin system Journal Article


Author(s): Nikolic, Nela
Article Title: Autoregulation of bacterial gene expression: lessons from the MazEF toxin–antitoxin system
Affiliation IST Austria
Abstract: Autoregulation is the direct modulation of gene expression by the product of the corresponding gene. Autoregulation of bacterial gene expression has been mostly studied at the transcriptional level, when a protein acts as the cognate transcriptional repressor. A recent study investigating dynamics of the bacterial toxin–antitoxin MazEF system has shown how autoregulation at both the transcriptional and post-transcriptional levels affects the heterogeneity of Escherichia coli populations. Toxin–antitoxin systems hold a crucial but still elusive part in bacterial response to stress. This perspective highlights how these modules can also serve as a great model system for investigating basic concepts in gene regulation. However, as the genomic background and environmental conditions substantially influence toxin activation, it is important to study (auto)regulation of toxin–antitoxin systems in well-defined setups as well as in conditions that resemble the environmental niche.
Journal Title: Current Genetics
ISSN: 1432-0983
Publisher: Springer  
Date Published: 2018-08-21
Start Page: epub ahead of print
Copyright Statement: CC BY 4.0
Sponsor: ISTFELLOW
DOI: 10.1007/s00294-018-0879-8
Open access: yes (OA journal)