Epigenetic cues modulating the generation of cell type diversity in the cerebral cortex Journal Article


Author(s): Amberg Nicole; Laukoter, Susanne; Hippenmeyer, Simon
Article Title: Epigenetic cues modulating the generation of cell type diversity in the cerebral cortex
Affiliation IST Austria
Abstract: The cerebral cortex is composed of a large variety of distinct cell-types including projection neurons, interneurons and glial cells which emerge from distinct neural stem cell (NSC) lineages. The vast majority of cortical projection neurons and certain classes of glial cells are generated by radial glial progenitor cells (RGPs) in a highly orchestrated manner. Recent studies employing single cell analysis and clonal lineage tracing suggest that NSC and RGP lineage progression are regulated in a profound deterministic manner. In this review we focus on recent advances based mainly on correlative phenotypic data emerging from functional genetic studies in mice. We establish hypotheses to test in future research and outline a conceptual framework how epigenetic cues modulate the generation of cell-type diversity during cortical development. This article is protected by copyright. All rights reserved.
Journal Title: Journal of Neurochemistry
Publisher: Wiley-Blackwell  
Publication Place: England
Date Published: 2018-10-01
Start Page: epub ahead of print
Copyright Statement: This article is protected by copyright. All rights reserved.
DOI: 10.1111/jnc.14601
Notes: This work was supported by IST Austria institutional funds; NÖ Forschung und Bildung n[f+b] (C13-002) to SH; a program grant from the Human Frontiers Science Program (RGP0053/2014) to SH; the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement No 618444 to SH, and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 725780 LinPro)to SH.
Open access: no